Arsenal
Granit Xhaka has returned from suspension and will likely partner Thomas Partey in midfield.
As a result, Nicolas Pepe may be pushed to the bench, allowing Emile Smith Rowe to take his place on the front line.
Kierney is a doubt for the home team, but he is expected to recover in time for the derby on Sunday.
Tottenham
Nuno Espirito Santo is concerned about the fitness of Lucas Moura, Ryan Sessegnon, and Steven Bergwijn for the trip to Arsenal.
Oliver Skipp, who came off the bench against Chelsea last week, is set to make his comeback at the expense of Tanguy Ndombele.
Santo may revert to a 4-3-3 formation, with Harry Kane leading the charge after a more reserved performance against Chelsea.
Prediction
Arsenal made it two league wins in a row with a 1-0 victory over Burnley at Turf Moor, as they continue to improve after a slow start to the season.
Tottenham lost 3-0 in the league for the second time in a row on Sunday, with a second-half collapse to Chelsea putting a damper on what had been a promising start to the season.
The Gunners haven’t lost a home league match to Spurs since 2010, and given the two teams’ current form, that streak looks set to continue on Sunday.
The Gunners have won back-to-back games against Norwich City and Burnley, with Martin Odegaard scoring the game-winning free kick against the latter.
Mikel Arteta also saw his side advance to the fourth round of the EFL Cup with a 3-0 win over AFC Wimbledon on Wednesday night, with Alexandre Lacazette, Emile Smith Rowe, and Eddie Nketiah scoring.
Arsenal possible starting lineup:
Ramsdale; Tomiyasu, Gabriel, White, Tierney; Odegaard, Lokonga, Smith Rowe; Aubameyang, Lacazette, Saka
Tottenham possible starting lineup:
Lloris; Reguilon, Dier, Romero, Emerson; Dele Alli, Ndombele, Hojbjerg; Son, Kane, Lo Celso
Our Prediction: Arsenal 2 – 1 Tottenham