Meanwhile, the Italian giants are aiming for their fourth victory in five matches across all competitions, as well as to extend their unbeaten run against the Blues to four games.
Juventus
Both Paulo Dybala and Alvaro Morata were substituted in Juventus’ 3-2 win over Sampdoria on Sunday, with the former almost certainly out against Chelsea.
Kaio Jorge and Arthur are also out for the Serie A club.
Dejan Kulusevski is expected to fill in for Dybala up front alongside Moise Kean.
Chelsea
Mason Mount was injured in the 1-0 loss to Manchester City and will be evaluated before the trip to Turin.
Reece James and Jorginho were both forced off in the defeat, with the latter more likely to be passed fit than the former, while Christian Pulisic is out.
Thiago Silva is expected to start at center-back, with Cesar Azpilicueta shifting to right wing-back to cover for James.
Hakim Ziyech and Kai Havertz are also set to be recalled.
Prediction
Juventus won back-to-back league games on Sunday, following up a 3-2 win over Spezia in midweek with a 3-2 win over Sampdoria, but the victory came at a cost, as both Paulo Dybala and Alvaro Morata were injured. Their absence on Wednesday is a huge setback.
Chelsea’s unbeaten league start to the season came to an end on Saturday when they were defeated 1-0 by Manchester City. This will be the Blues’ first meeting with the Old Lady since a 3-0 defeat in Turin in 2012.
Given Juventus’ poor start to the season, Chelsea should be able to recover from Saturday’s disappointment.
Chelsea’s defensive stability has been one of the club’s standout qualities since Tuchel took over as manager. Juventus are typically known for their defensive abilities, but in 2021 they have appeared surprisingly vulnerable, keeping only one clean sheet in their last 21 games across all competitions.
Both teams will regard Wednesday’s game as a “must-win” if they are to take first place in Group H. A hard-fought match is expected in Turin, but the Blues are expected to win by a slim margin.
Juventus possible starting lineup:
Perin; Danilo, Chiellini, Bonucci, Sandro; Bentancur, Locatelli, Ramsey; Chiesa, Kean, Kulusevski
Chelsea possible starting lineup:
Mendy; Christensen, T. Silva, Rudiger; Azpilicueta, Kovacic, Jorginho, Alonso; Havertz, Lukaku, Werner
Our Prediction: Juventus 0-1 Chelsea