While the Foxes are coming off a defeat to English champions Manchester City, their Neapolitan opponents beat old rivals Juventus with a late goal to keep their perfect Serie A record.
Leicester City
Ayoze Perez is serving a three-game domestic ban but will be available for selection on Thursday.
Jonny Evans is set to make his first start of the season after recovering from injury, but Leicester are still without Wesley Fofana, James Justin, and Nampalys Mendy.
Patson Daka has only played 26 minutes in the Premier League so far, but he will almost certainly start on Thursday.
Napoli
Napoli could be missing seven players when they travel to Leicester on Thursday.
Lorenzo Insigne and Mario Rui have added to Napoli’s injury list, and both are expected to miss midweek.
Hirving Lozano could get some much-needed minutes in Insigne’s absence, but someone will have to play out of position to cover Rui at left-back.
Piotr Zielinski, at least, returned from injury in the weekend’s 2-1 win over Juventus.
If the away team requires fresh legs, Juan Jesus and Kevin Malcuit are options in defense.
Prediction
Leicester was defeated 1-0 at home by Manchester City on Saturday, and they have now lost two of their first four matches this season.
Napoli will be buoyed by their weekend comeback victory over Serie A rivals Juventus.
Napoli have won their first three league games this season and will be hoping to take something on Thursday.
On Thursday night, an open game is expected because both teams prefer to go forward and are capable of slicing open even the tightest defenses.
Though Leicester has struggled in the final third recently, the bright lights of a European night – and perhaps a change in attacking personnel – can help them secure a point against their toughest Group C opponents.
Leicester City possible starting lineup:
Schmeichel; Castagne, Vestergaard, Soyuncu, Bertrand; Albrighton, Tielemans, Ndidi, Barnes; Daka, Vardy
Napoli possible starting lineup:
Ospina; Di Lorenzo, Manolas, Koulibaly, Rui; Anguissa, Elmas, Ruiz; Politano, Osimhen, Lozano
Our Prediction: Leicester City 2-2 Napoli