The Reds are aiming for their seventh European title this season, while Milan are aiming for their eighth triumph on the continent.
Liverpool
Harvey Elliott, the midfielder who suffered a horrific leg injury in Sunday’s win over Leeds, will be out for an extended period of time for Liverpool, while Roberto Firmino remains out injured.
AC Milan
Olivier Giroud, who left Chelsea this summer, could make a quick return to England after returning from a Covid-imposed absence.
Prediction
Liverpool will undoubtedly be boosted to victory in this clash between historically two heavyweights on the first European night at Anfield with a crowd since the now-infamous clash with Atletico Madrid as the coronavirus pandemic was first taking hold in the UK.
With both of these European behemoths making quick starts to domestic title challenges and looking to carry that momentum over to continental competition, a tense and closely fought battle should be in store on Merseyside.
There is a brief but well-documented history between Liverpool and AC Milan in the Champions League, but we don’t see either side gaining an advantage and are betting on a score draw in Wednesday’s opener.
Liverpool possible starting lineup:
Alisson; Alexander-Arnold, Van Dijk, Matip, Robertson; Henderson, Fabinho, Thiago; Salah, Jota, Mane
AC Milan possible starting lineup:
Maignan; Calabria, Tomori, Romagnoli, Hernandez; Kessie, Tonali; Florenzi, Diaz, Rebic; Ibrahimovic
Our Prediction: Liverpool 1-1 AC Milan