Sergio Conceicao’s side began their European campaign with a goalless draw against Atletico Madrid, while the Reds defeated AC Milan 3-2 at Anfield.
Chancel Mbemba is suspended following his red card in Madrid two weeks ago, and with Pepe doubtful, Ivan Mercano could partner Fabio Cardoso at the back.
Agustin Marchesin is nearing a return to fitness, but Sergio Conceicao is expected to stick with Diogo Costa following his penalty save against Gil Vicente on Friday.
Marko Grujic is available and should get the start against his former club.
Neco Williams will be evaluated but is unlikely to start, while Jurgen Klopp is missing midfield trio Naby Keita, Thiago, and Harvey Elliott.
Klopp may make some changes for the weekend’s match against Manchester City, with Roberto Firmino, Joe Gomez, Kostas Tsimikas, and Ibrahima Konate all expected to play.
Curtis Jones and James Milner are vying for the final midfield spot, which will be shared by Fabinho and Jordan Henderson.
Porto’s unbeaten start to the season was extended with a 2-1 victory at Gil Vicente on Friday night. They’ll be hoping to hold Liverpool on Tuesday night after a 0-0 draw in Madrid earlier this month.
The Reds were punished for their frivolity with a 3-3 draw at Brentford on Saturday evening. They didn’t lose ground in the title race because other results went their way, and the stalemate meant they, like Porto, remained unbeaten.
Porto could be without their first-choice center-back pairing in midweek, which could hurt their chances of beating the Reds.
Porto have already proven to be a tough nut to crack this season, both domestically and on the continent, and their home record in the group stages speaks for itself, but some forced defensive changes could hurt them this week.
Klopp cannot afford to take any of the Group B games lightly, and must also consider the upcoming visit of Manchester City, but we believe a rotated Reds side will still have enough firepower to come away with all three points in a close game.
Porto possible starting lineup:
Costa; Corona, Cardoso, Marcano, Wendell; Otavio, Oliveira, Grujic, Diaz; Taremi, Martinez
Liverpool possible starting lineup:
Alisson; Alexander-Arnold, Matip, Gomez, Tsimikas; Henderson, Fabinho, Jones; Salah, Firmino, Minamino
Our Prediction: Porto 1-2 Liverpool