Dortmund, meanwhile, will be determined to bounce back from their 4-2 thrashing at the hands of Bayern Munich at the weekend.
- Leipzig may not rush Christopher Nkunku back from a hamstring issue for this match, especially with their top-four hopes damaged by their recent defeat to Mainz.
- Dani Olmo is likely to start, though, after appearing as a substitute during the 3-0 loss, while the likes of Mohamed Simakan, Amadou Haidara and David Raum will expect to come into the starting XI after being left out on Saturday.
- Peter Gulasci, Xaver Schlager and Yussuf Poulsen all remain sidelined by long-term injuries.
- Dortmund, meanwhile, will travel without Thomas Meunier, Mateu Morey, Julian Duranville and Abdoulaye Kamara due to existing injuries. While Nico Schlotterbeck suffered a hip issue against Bayern and is unlikely to return until later this month.
- Mats Hummel replaced his compatriot during the first half and should start at Red Bull Arena, while Karim Adeyemi could feature after returning from a recent muscle strain to make the bench in Munich.
- Donyell Malen scored as a late substitute and will expect to start, with the likes of Youssoufa Moukoko, Salih Ozcan and Alexander Meyer also firmly in contention,
RB leipzig: Blaswich; Simakan, Orban, Gvardiol, Raum; Laimer, Haidara; Szoboszlai, Olmo; Silva, Werner
Borussia Dortmund: Meyer; Morey, Sule, Hummels, Guerreiro; Ozcan, Can, Bellingham; Brandt, Moukoko, Malen
This has all the makings of an excellent cup tie, with both teams recognising that the DFB-Pokal represents their best chance of winning silverware this season.
Dortmund could be bruised by their defeat to Bayern on Saturday, with home advantage potentially set to be a key factor in helping Leipzig remain in the hunt to retain this trophy.
Our prediction is RB Leipzig 2-1 Borussia Dortmund